Reduction of Cholesterol and Fasting Blood Sugar Levels by One Month Supplementation of Fresh Garlic in Diabetic Libyan Patients: A Double Blind, Baseline Controlled Study.

Ali Idris Banigesh, Aeda R. Hamad, Abtesam A. Dihom, Idris Mohamed El-Mahdi

Abstract

Background:   The therapeutic effects of fresh garlic remain controversial. The aim of this study is to investigate whether supplementation of fresh garlic could improve blood glucose and cholesterol profile in Libyan diabetic patients with moderate blood cholesterol.

 Methods:   Forty-six diabetic patients were randomly assigned to either fresh garlic alone  (≈2 grams/day), or fresh garlic in combination with glibenclamide taken on an empty stomach every morning for a month. Serum blood glucose, cholesterol and blood pressure were measured before starting treatment and after the end of the treatment period.

 Results: Fresh garlic alone was able to decrease the mean serum cholesterol levels by 26 mg/dl (84% of the original base values), while the combination of fresh garlic and glibenclamide produced a 28 mg/dl  decrease in the mean serum cholesterol (85% of the original base values). Fresh garlic alone was able as well to decrease the mean blood glucose levels by 20 mg/dl (85% of the original base values), while the combination of fresh garlic and glibenclamide produced a 60 mg/dl decrease in the serum glucose levels (72% of the original base values). Neither treatment had a significant effect on the mean systolic or diastolic blood pressures after 30 days of treatment.

 Conclusion: Administration of fresh garlic every morning for a month significantly reduced the blood cholesterol and fasting blood glucose levels in diabetic patients. Thus administering dietary fresh garlic daily to diabetic patients might have cardio-protective effects on diabetic patients. 

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References

Nesto RW. Beyond Low-Density Lipoprotein. American Journal of Cardiovascular Drugs. 2005;5(6):379-87.

Hauner D, Hauner H. Metabolic syndrome and breast cancer: is there a link?. Breast Care. 2014;9(4):277-81.

Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013;5(4):1218-40.

Zalesin KC, Franklin BA, Miller WM, Peterson ED, McCullough PA. Impact of obesity on cardiovascular disease. Endocrinology and metabolism clinics of North America. 2008;37(3):663-84.

Sheweita SA, Newairy AA, Mansour HA, Yousef MI. Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats. Toxicology. 2002;174(2):131-39.

Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME. ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicology and applied pharmacology. 2010;244(1):77-83.

Eidi M, Eidi A, Saeidi A, Molanaei S, Sadeghipour A, Bahar M, Bahar K. Effect of coriander seed (Coriandrum sativum L.) ethanol extract on insulin release from pancreatic beta cells in streptozotocin-induced diabetic rats. Phytother Res. 2009;23(3):404-06.

Jung YM, Lee SH, Lee DS, You MJ, Chung IK, Cheon WH, Kwon YS, Lee YJ, Ku SK. Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutrition research. 2011;31(5):387-96.

Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D. Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice. Oxidative medicine and cellular longevity. 2012;2012.

Pintana H, Sripetchwandee J, Supakul L, Apaijai N, Chattipakorn N, Chattipakorn S. Garlic extract attenuates brain mitochondrial dysfunction and cognitive deficit in obese-insulin resistant rats.

Applied Physiology, Nutrition, and Metabolism. 2014;39(12):1373-79.

Al-Qattan KK, Alnaqeeb MA, Ali M. The antihypertensive effect of garlic (Allium sativum) in the rat two-kidney–one-clip Goldblatt model. Journal of ethnopharmacology. 1999;66(2):217-22.

Drobiova H, Thomson M, Al-Qattan K, Peltonen-Shalaby R, Al-Amin Z, Ali M. Garlic increases antioxidant levels in diabetic and hypertensive rats determined by a modified peroxidase method.

Evidence-Based Complementary and Alternative Medicine. 2010;2011.

Chaupis-Meza D, Rojas J, Gasco M, Gonzales GF. Hypotensive effect of extract of macerated garlic (Allium sativum) for 18 weeks in an in vivo experimental model. Revista peruana de medicina experimental y salud publica. 2014;31(3):461-66.

Castro C, Lorenzo AG, González A, Cruzado M. Garlic components inhibit angiotensin II‐induced cell‐cycle progression and migration: Involvement of cell‐cycle inhibitor p27Kip1 and mitogen‐activated protein kinase. Molecular nutrition & food research. 2010;54(6):781-87.

Ried K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integrated blood pressure control. 2014;7:71.

Ahmad MS, Pischetsrieder M, Ahmed N. Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts. European journal of pharmacology. 2007;561(1):32-8.

Lau BH. Suppression of LDL oxidation by garlic. The Journal of nutrition. 2001;131(3):985S-8S.

Dinkova‐Kostova AT, Talalay P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Molecular nutrition & food research. 2008;52(S1).

Juurlink BH. Can dietary intake of phase 2 protein inducers affect the rising epidemic of diseases such as type 2 diabetes?. MedGenMed: Medscape general medicine. 2003;5(4):25-7.

Senanayake GV, Banigesh A, Wu L, Lee P, Juurlink BH. The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats. American journal of hypertension. 2012;25(2):229.

Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci. 2011;24(4):565-70.

Ashraf R, Aamir K, Shaikh AR, Ahmed T. Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J Ayub Med Coll Abbottabad. 2005;17(3):60-4.

Pittler MH, Ernst E. Clinical effectiveness of garlic (Allium sativum). Molecular nutrition & food research. 2007;51(11):1382-85.

Kwak JS, Kim JY, Paek JE, Lee YJ, Kim HR, Park DS, Kwon O. Garlic powder intake and cardiovascular risk factors: a meta-analysis of randomized controlled clinical trials. Nutrition research and practice. 2014;8(6):644-54.

Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutrition reviews. 2013;71(5):282-99.

Reinhart KM, Talati R, White CM, Coleman CI. The impact of garlic on lipid parameters: a systematic review and meta-analysis. Nutrition research reviews. 2009;22(01):39-48.

Turner B, Mølgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. The British journal of nutrition. 2004;92(4):701-06.

Endo A, Imai Y, Nakamura M, Yanagisawa E, Taguchi T, Torii K, Okumura H, Ichinose K. Distinct intraspecific variations of garlic (Allium sativum L.) revealed by the exon–intron sequences of the alliinase gene. Journal of natural medicines. 2014;68(2):442-47.

Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y. Intake of garlic and its bioactive components. The Journal of nutrition. 2001;131(3):955S-62S.

Fardet A, Boirie Y. Associations between food and beverage groups and major diet-related chronic diseases: an exhaustive review of pooled/meta-analyses and systematic reviews. Nutrition reviews. 2014;72(12):741-62.

Shouk R, Abdou A, Shetty K, Sarkar D, Eid AH. Mechanisms underlying the antihypertensive effects of garlic bioactives. Nutrition Research. 2014;34(2):106-15.

Imai J, Ide N, Nagae S, Moriguchi T, Matsuura H, Itakura Y. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta medica. 1994;60(05):417-20.

Arivazhagan S, Balasenthil S, Nagini S. Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG)‐induced gastric carcinogenesis in rats. Phytotherapy Research. 2000;14(4):291-93.

Banerjee SK, Dinda AK, Manchanda SC, Maulik SK. Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury. BMC pharmacol. 2002;2(16):1-9.

Zhao Y, Biggs TD, Xian M. Hydrogen sulfide (H 2 S) releasing agents: chemistry and biological applications. Chemical Communications. 2014;50(80):11788-805.

Khatua TN, Adela R, Banerjee SK. Garlic and cardioprotection: insights into the molecular mechanisms 1. Canadian journal of physiology and pharmacology. 2013;91(6):448-58.

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