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ORIGINAL ARTICLE
Year : 2020  |  Volume : 5  |  Issue : 2  |  Page : 32-36

Correlation between maternal copper deficiency and premature rupture of membranes: A case–Control study


1 Department of Embryology, Faculty of Medicine, University of Aleppo, Aleppo, Syria
2 Analytical and Food Chemistry Department, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria

Correspondence Address:
Muhammad Mazketly
Faculty of Medicine, University of Aleppo, Aleppo
Syria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2519-139x.295916

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Background: The association between maternal serum copper levels and premature rupture of membranes (PROM) is debated. Aims: This study aims to study the relationship between maternal serum copper levels and the incidence of PROM and to determine risk factors of PROM in Aleppo University Hospital of Obstetrics and Gynecology. Settings and Design: Sixty pregnant women were subjected for this study. Materials and Methods: Pregnant women were subjected for analyzing serum copper concentrations. Maternal serum copper levels were measured by atomic absorption spectroscope. Statistical Analysis: By SPSS (version 22.0). Results: A significant correlation was found between maternal serum copper levels and the incidence of PROM. The relationship presents when copper level is considered as a categorical variable, as mothers with copper deficiency were significantly more vulnerable for PROM (Odds ratios = 0.15, confidence intervals: 0.04–0.61, P = 0.002). Furthermore, the relationship presents when copper level is considered as a numerical variable, as mothers with lower serum copper levels were at significantly higher risk to develop PROM. Difference in means between the two groups was 40.87 μg/dL with CI (14.98–66.75) μg/dL (P = 0.003). Conclusion: Within its limitations, this study suggests a significant relationship between maternal serum copper levels and PROM.


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