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ORIGINAL RESEARCH ARTICLE
Year : 2017  |  Volume : 2  |  Issue : 1  |  Page : 47-54

Reduction of cholesterol and fasting blood sugar levels by one month supplementation of fresh garlic in diabetic Libyan patients: A double blind, baseline controlled study


1 Department of Pharmacology, Faculty of Medicine, University of Saskatchewan, Canada
2 Department of Pharmacology, Faculty of Pharmacy, University of Benghazi, Libya
3 Department of Pharmaceutics, Faculty of Pharmacy, University of Benghazi, Libya

Correspondence Address:
I M El-Mahdi
Department of Pharmaceutics, Faculty of Pharmacy, University of Benghazi
Libya
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Source of Support: None, Conflict of Interest: None


DOI: 10.21502/limuj.007.02.2017

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Background: The therapeutic effects of fresh garlic remain controversial. The aim of this study is to investigate whether supplementation of fresh garlic could improve blood glucose and cholesterol profile in Libyan diabetic patients with moderate blood cholesterol. Methods: Forty-six diabetic patients were randomly assigned to either fresh garlic alone (≈2 grams/day), or fresh garlic in combination with glibenclamide taken on an empty stomach every morning for a month. Serum blood glucose, cholesterol and blood pressure were measured before starting treatment and after the end of the treatment period. Results: Fresh garlic alone was able to decrease the mean serum cholesterol levels by 26 mg/dl (84% of the original base values), while the combination of fresh garlic and glibenclamide produced a 28 mg/dl decrease in the mean serum cholesterol (85% of the original base values). Fresh garlic alone was able as well to decrease the mean blood glucose levels by 20 mg/dl (85% of the original base values), while the combination of fresh garlic and glibenclamide produced a 60 mg/dl decrease in the serum glucose levels (72% of the original base values). Neither treatment had a significant effect on the mean systolic or diastolic blood pressures after 30 days of treatment. Conclusion: Administration of fresh garlic every morning for a month significantly reduced the blood cholesterol and fasting blood glucose levels in diabetic patients. Thus administering dietary fresh garlic daily to diabetic patients might have cardio-protective effects on diabetic patients.


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